Comparative Analysis Between Oral Leukoplakia and Proliferative Verrucous Leukoplakia (lvp) and Characterization of Immunoexpression of Cytokeratin-19 in Lvp
Name: Emanuely Ronconi da Fonseca
Type: MSc dissertation
Publication date: 15/05/2020
Advisor:
Name |
Role |
|---|---|
| Danielle Resende Camisasca Barroso | Advisor * |
Examining board:
| Name |
Role |
|---|---|
| Danielle Resende Camisasca Barroso | Advisor * |
| Liliana Aparecida Pimenta de Barros | Internal Examiner * |
| Sonia Alves Gouvea | External Alternate * |
Summary: Objectives: To survey and review the cases diagnosed as oral leukoplakia (OL) at the UFES Department of Oral Pathological Anatomy, from 2009 to 2017, describe the clinical and socio-demographic histopathological characteristics, apply the criteria for proliferative verrucous leukoplakia (PVL) proposed by Cerero- Lapiedra et al. (2010) and Villa et al. (2018) and perform PVL immunohistochemistry. Methods: From the records of the Oral Pathological Anatomy Service of the UFES Dentistry Course, all cases diagnosed as OL from 2009 to 2017 were surveyed. Histopathological requests, records and medical records were accessed to collect socio-demographic data, habits
and clinical data. The histopathological slides of each case were reviewed. The data were subjected to descriptive analysis (means, medians and proportions) and the association of variables with the diagnostic categories obtained by the chi-square test.Results: Of the 97 patients diagnosed with OL, 18 met the criteria for PVL-Cerero, of these 83.33% (n=15) were female and 16.17% (n=3) were male, and 8 met the criteria for PVL-Villa, of these 75% (n=6) female and 25% (n=2) male. The average age found was 61.22 and 57.75 years, respectively. Regarding habits, in the PVL-Cerero 66.67%
of the patients declared they were not smokers (n=12) and in the PVL-Villa the number of smokers and non-smokers was equal, 37.5% (n=3). There was an association of PVL with multiple affected sites (p=0.08 and 0.016). Most injuries were white, 81.48% (n=44) in PVL-Cerero and 92.31% (n=24) in PVL-Villa and did not have a smooth surface (n=38, 70.37% and n=17, 65.38%, respectively). The tongue was more affected (n=21, 38.89%) in the PVL-Cerero and the jugal mucosa (n=12, 42.86%) in the PVL-Villa. There was a malignant transformation in two cases of PVL. There was an association of the granular layer with PVL-Villa (p=0.03), an association of ortho and paraceratin simultaneously with PVL-Villa (p=0.004), an association of degeneration of the basal layer with PVL-Cerero (p=0.039) and association of the distribution of the inflammatory infiltrate with both (p=0.004 and 0.003). Conclusion: The diagnostic criteria applied were useful to identify cases of PVL and can be applied in clinical practice. The LVP profile differs from the classic profile of the patient who develops oral cancer, affecting more non-smoking women.
